Microbial-induced immunomodulation by targeting the NF-kappa B system

作者：Neish Andrew S; Naumann Michael^*

来源：Trends in Microbiology, 2011, 19(12): 596-605.

DOI：10.1016/j.tim.2011.08.004

Virtually all eukaryotes have developed defense mechanisms to efficiently counter potential threats from prokaryotic microorganisms; an example is the conserved nuclear factor-kappaB (NF-kappa B) signaling system. However, bacterial pathogens and commensals have in turn evolved highly effective counter mechanisms to modulate this immune regulatory circuit. Modifications in ubiquitin, ubiquitin-like (Ubl) proteins such as neural precursor cell expressed, developmentally down-regulated 8(NEDD8) and other post-translational modifications (PTMs) in the NF-kappa B system represent attractive targets for microbial manipulation. In this review, we describe recent advances in understanding the different strategies that bacteria have evolved to interfere with PTMs in NF-kappa B signal transmission.

• 出版日期2011-12