Maternal hyperthyroidism increases the susceptibility of rat adult offspring to cardiovascular disorders

作者：Lino Caroline A; da Silva Ivson Bezerra; Shibata Caroline E R; Monteiro Priscilla de S; Barreto Chaves Maria Luiza M

来源：Molecular and Cellular Endocrinology, 2015, 416(C): 1-8.

DOI：10.1016/j.mce.2015.08.015

• Gestational hyperthyroidism
• Cardiac renin-angiotensin system
• Fetal programming

Suboptimal intrauterine conditions as changed hormone levels during critical periods of the development are considered an insult and implicate in physiological adaptations which may result in pathological outcomes in later life. This study evaluated the effect of maternal hyperthyroidism (hyper) on cardiac function in adult offspring and the possible involvement of cardiac Renin-Angiotensin System (RAS) in this process. Wistar dams received orally thyroxin (12 mg/L) from gestational day 9 (GD9) until GD18. Adult offspring at postnatal day 90 (PND90) from hyper dams presented increased SBP evaluated by plethysmography and worse recovery after ischemia-reperfusion (I/R), as evidenced by decreased LVDP, dP/dT and dP/dT at 25 min of reperfusion and by increased infarct size. Increased cardiac Angiotensin I/II levels and AT1R in hyper offspring were verified. Herein, we provide evidences that maternal hyperthyroidism leads to altered expression of RAS components in adult offspring, which may be correlated with worse recovery of the cardiac performance after ischemic insults and hypertension.

• 出版日期2015-11-15