Asymmetric synthesis of novel tetrahydroquinoline derivatives with a sugar building block and their bioactivities

作者：Liu HM^*; Liu FW; Zou DP; Dai GF

来源：Bioorganic & Medicinal Chemistry Letters, 2005, 15(7): 1821-1824.

DOI：10.1016/j.bmcl.2005.02.024

• asymmetric synthesis
• carbohydrates
• building block
• tetrahydroquinoline
• bioactivity

Some novel spiro-tetrahydroquinolines were stereoselectively synthesized by using keto-sugar derived from sucrose as a building block in one pot under mild conditions. The in vitro immunobiological activity and cytotoxicity of these novel tetrahydroquinolines were investigated. The results implied that these spiro-compounds have obvious bioactivity and may be structurally modified to improve bioactivity further.

• 出版日期2005-4-1
• 单位郑州大学