A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and gamma-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

作者:Lee Wonhwa; Seo Junyoung; Kwak Soyoung; Park Eun Ji; Na Dong Hee; Kim Soyoun; Lee You Mie; Kim In San*; Bae Jong Sup
来源:Advanced Materials, 2015, 27(42): 6637-+.
DOI:10.1002/adma.201503093

摘要

New protein nanocages are designed bearing two functional proteins, gamma-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.

  • 出版日期2015-11-11