The ups and downs of p53: understanding protein dynamics in single cells

作者:Batchelor Eric; Loewer Alexander; Lahav Galit*
来源:Nature Reviews Cancer, 2009, 9(5): 371-377.
DOI:10.1038/nrc2604

摘要

Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence. understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.

  • 出版日期2009-5