摘要
9-Aminoacridine (9-AA) is an important attractive pharmaceutical drug employed as chemotheraptic agent for wound dressings. However, 9-AA possesses limited solubility and rapid metabolic decomposition renders this potential drug to limit its applications. Here we propose Cyclodextrins (CDs) as a drug carrier to improve the bioavailability, solubility of 9-AA. The interaction between 9-AA and CDs (alpha-CD and beta-CD) has been studied using UV-Vis absorption, steady state time resolved fluorescence, H-1 NMR and FT-IR spectroscopy techniques. The spectroscopic measurements show that 9-AA does not form stable complex with alpha-CD and also confirmed by DFT calculations. On the other hand, 9-AA forms inclusion complex with beta-CD in a 1:1 stoichiometry ratio. Our DFT results suggest that 9-AA stabilizes inside the CD environment through hydrogen bonding that has unambiguously confirmed by AIM analysis. Thus our studies provide a useful insights in the development of Aminoacridine based drugs & its delivery through a suitable carrier like CDs.
- 出版日期2013-2-15