Association of Interleukin-10 A-592C Polymorphism in Taiwanese Children with Kawasaki Disease

作者：Hsueh Kai Chung; Lin Ying Ju; Chang Jeng Sheng; Wan Lei; Tsai Yu Hsin; Tsai Chang Hai; Chen Chih Ping; Tsai Fuu Jen^*

来源：Journal of Korean Medical Science, 2009, 24(3): 438-442.

DOI：10.3346/jkms.2009.24.3.438

• Mucocutaneous Lymph Node Syndrome
• Polymorphism
• Interleukin-10

Elevated serum levels of interleukin-10 (IL-10) have been reported in patients with Kawasaki disease (KD). IL-10 reduces the inflammatory actions of macrophages and T cells and it may play a significant role in the regulation of inflammatory vascular damage associated with systemic vasculitis. The aim of this study was to examine whether -592 IL-10 promoter polymorphism is a susceptibility or severity marker of KID in Chinese patients in Taiwan. The study included 105 KD patients and 100 normal controls. Genotype and allelic frequencies for the IL-10 gene polymorphism in both groups were compared. There were no significant between-group differences in the genotype distribution of IL-10 A-592C gene polymorphism (P=0.08). However, the frequency of the -592*A allele was significantly increased in the patients with KD compared with controls (71.9% vs. 61.0%, P=0.019). The odds ratio for developing KD in individuals with IL-10 -592*A allele was 1.64 (95% confidence interval, 1.06-2.52) compared to individuals with the IL-10-592*C allele. No significant difference was observed in the genotype and allelic frequencies for the IL-10 A-592C polymorphism between patients with and without coronary artery lesions. The IL-10-592*A allele may be involved in the development of KD in Taiwanese children.

• 出版日期2009-6
• 单位中国医科大学