First Evidence of Palytoxin and 42-Hydroxy-palytoxin in the Marine Cyanobacterium Trichodesmium

作者：Kerbrat Anne Sophie; Amzil Zouher; Pawlowiez Ralph; Golubic Stjepko; Sibat Manoella; Darius Helene Taiana; Chinain Mireille; Laurent Dominique^*

来源：Marine Drugs, 2011, 9(4): 543-560.

DOI：10.3390/md9040543

• cyanobacteria
• Trichodesmium
• palytoxin
• 42-hydroxy-palytoxin
• clupeotoxism

Marine pelagic diazotrophic cyanobacteria of the genus Trichodesmium (Oscillatoriales) are widespread throughout the tropics and subtropics, and are particularly common in the waters of New Caledonia. Blooms of Trichodesmium are suspected to be a potential source of toxins in the ciguatera food chain and were previously reported to contain several types of paralyzing toxins. The toxicity of water-soluble extracts of Trichodesmium spp. were analyzed by mouse bioassay and Neuroblastoma assay and their toxic compounds characterized using liquid chromatography coupled with tandem mass spectrometry techniques. Here, we report the first identification of palytoxin and one of its derivatives, 42-hydroxy-palytoxin, in field samples of Trichodesmium collected in the New Caledonian lagoon. The possible role played by Trichodesmium blooms in the development of clupeotoxism, this human intoxication following the ingestion of plankton-eating fish and classically associated with Ostreopsis blooms, is also discussed.

• 出版日期2011-4