A novel chiral electrochemiluminescence sensor that can discriminate proline enantiomers

作者：Wang Qinghong; Lin Xia; Guo Dongmei; Xu Juanjuan; Xuan Chunzhi; Chen Cui; Fu Yingzi^*

来源：RSC Advances, 2015, 5(114): 94338-94343.

DOI：10.1039/c5ra13528a

A sensitive, stable and stereoselective electrochemiluminescence (ECL) sensor has been designed to enantioselectively discriminate proline enantiomers by immobilizing Ru(bpy)(3)(2+)-gold nanoparticles (Ru-AuNPs) and beta-cyclodextrin-reduced graphene oxide (beta-CD-rGO) on glassy carbon electrode. More Ru(bpy)(3)(2+) could be immobilized on the surface of electrode stably via preparing Ru-AuNPs and better stereoselectivity could be introduced to the sensor via the synthesis of beta-CD-rGO. When the developed sensor interacted with proline enantiomers, obvious difference of ECL intensities towards L- and D-proline was observed, and a larger intensity was obtained from D-proline. As a result, ECL technique might act as a promising method to chiral recognition of amino acids enantiomers or chiral drugs.

• 出版日期2015
• 单位西南大学