Phytochemical and biological studies of Sisymbrium irio L. Growing in Saudi Arabia

作者：Al Jaber Nabila AbdulAziz^*

来源：Journal of Saudi Chemical Society, 2011, 15(4): 345-350.

DOI：10.1016/j.jscs.2011.04.010

• Flavonoids
• Sisymbrium irio
• Antioxidant activities
• Apigenin
• Apigenin-7-di-glucoside

Ten flavonoids were isolated for the first time from the aerial parts of Sisymbrium irio L. grown in Saudia Arabia, using chromatographic methods, and identified as apigenin, apigenin-7-galactoside, apigenin-7-O-beta-D-glucoside, luteolin-7-O-glucoside, apigenin-7-di-glucoside 5, apigenin-7-O-(6 '' acetyl) glucoside, apigenin-7-O-gluco(6 ''-1''') rhamnoside, apigenin-7-O-gluco (6 ''-1''')rhamnoside-5-methoxide, kampferol and kampferol-3-xyloside-7-galactoside. The median lethal dose of the extract was determined in mice and found to be greater than 5000 mg/kg body weight, suggesting that this plant is non-toxic. Antioxidant activities were assessed for all extracts and fractions (total, ether, chloroform, ethyl acetate and butanol) and isolated compounds, and showed variable antioxidant activity, with apigenin-7-O-galactoside being the most potent.

• 出版日期2011-10