Antenatal depressive symptoms increase the likelihood of preterm birth

作者：Straub Heather; Adams Marci; Kim J Jo; Silver Richard K^*

来源：American Journal of Obstetrics and Gynecology, 2012, 207(4): 329.e1.

DOI：10.1016/j.ajog.2012.06.033

• perinatal depression
• preterm birth

OBJECTIVE: We evaluated the relationship between antenatal depressive symptoms and preterm birth.
STUDY DESIGN: Patients completed the Edinburgh Postnatal Depression Scale between 24-28 weeks of gestation. A score >= 12 (or thoughts of self-harm) indicated an at-risk woman. Symptomatic women were compared to risk-negative patients for relevant demography, historical variables, and pregnancy outcome.
RESULTS: After screening 14,175 women we found a screen positive rate of 9.1% (n = 1298). At-risk women had a significant increase in preterm birth at <37, <34, <32, and <28 weeks of gestation. Multi-variable analysis adjusting for maternal age, race/ethnicity, prior preterm delivery, and insurance status revealed a persistent association between antenatal depressive symptoms and preterm birth (adjusted odds ratio, 1.3; 95% confidence interval, 1.09-1.35), which was also observed after multiple gestations were excluded from the analysis (odds ratio, 1.7; 95% confidence interval, 1.38-1.99).
CONCLUSION: In this large cohort of prenatally screened women, those with depressive symptoms had an increased likelihood of preterm birth.

• 出版日期2012-10