Needle-free jet injection of DNA and protein vaccine of the Far-Eastern subtype of tick-borne encephalitis virus induces protective immunity in mice

作者：Omori Urabe Yuki; Yoshii Kentaro^*; Ikawa Yoshida Ayae; Kariwa Hiroaki; Takashima Ikuo

来源：Microbiology and Immunology, 2011, 55(12): 893-897.

DOI：10.1111/j.1348-0421.2011.00389.x

• DNA vaccine
• needle-free injection
• subviral particles
• tick-borne encephalitis

Tick-borne encephalitis virus (TBEV) causes severe encephalitis in humans. It is endemic in one area of Japan; however no commercial vaccine is available in that country. In this Japan-based study, the efficacy of subviral particles (SPs) of TBEV administered by needle-free injector was evaluated as a vaccine candidate. Inoculation with SP-encoding DNA by needle-free injector induced neutralizing antibodies more efficiently than when administered by needle and syringe, and mice vaccinated with one dose by needle-free injector survived challenge with a lethal dose of TBEV. These results suggest that SP vaccines delivered by needle-free injector can protect against TBEV infection.

• 出版日期2011-12