Dermoscopy, reflectance confocal microscopy and histopathology of an amelanotic melanoma from an individual heterozygous for MC1R and tyrosinase variant alleles

作者：Curchin Claudia^*; Wurm Elisabeth; Jagirdar Kasturee; Sturm Richard; Soyer Peter

来源：Australasian Journal of Dermatology, 2012, 53(4): 291-294.

DOI：10.1111/j.1440-0960.2012.00882.x

• 160W
• amelanotic melanoma
• melanocortin-1-receptor
• nodular melanoma
• red hair colour variant
• reflectance confocal microscopy
• rs1126809
• tyrosinase

We present a case of an amelanotic nodular melanoma occurring in a 26-year-old woman who carried a heterozygous (melancortin-1-receptor) MC1R 160R/W and tyrosinase (TYR) 402R/Q genotype and had a dark hair phenotype. We present dermoscopic, reflectance confocal microscopy (RCM) and histopathological images of the melanoma. We discuss the relationship between MC1R red hair colour (RHC) variants, TYR variants, phenotype and melanoma development. We also discuss the merits of RCM as an additional diagnostic aid for equivocal melanocytic lesions.

• 出版日期2012-11