Aberrant Expression of CXCR4 and beta-Catenin in Pancreatic Cancer

作者：Wang Zheng; Ma Qingyong^*; Li Pei; Sha Huanchen; Li Xuqi; Xu Jun

来源：Anticancer Research, 2013, 33(9): 4103-4110.

• Pancreatic cancer
• tumor progression
• CXCR4
• beta-catenin

Aim: The stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) axis and Wingless and INT-1 (Wnt)/beta-catenin pathway has been related to cancer progression. The aim of this study was to investigate the expression of CXCR4 and beta-catenin in pancreatic cancer. Patients and Methods: A total of 48 pancreatic cancer samples and 8 normal pancreatic tissues were selected to detect CXCR4 and beta-catenin expression by an immunohistological technique. Spearman and Chi-square analyses were used to study the relation between the protein expression and clinical characteristics. Survival analysis was evaluated by the Kaplan-Meier product limit method. Results: The proportions of CXCR4 and beta-catenin expression on pancreatic cancer cells were significantly higher than in normal pancreas tissues. There was a significant difference in CXRC4 expression levels, lymph node metastasis and TNM stage. Clinical Significance was observed for beta-catenin expression and lymph node metastasis; Kaplan-Meier curves suggested that clinical prognosis is poor for patients expressing CXCR4. Multivariate analysis showed that CXCR4 expression was an independent prognostic factor for pancreatic cancer. Conclusion: Both CXCR4 and beta-catenin are abnormally expressed in pancreatic cancer. CXCR4 may be an important marker for pancreatic cancer progression.

• 出版日期2013-9
• 单位西安交通大学