A novel viscous dissecting gel for endoscopic submucosal dissection: a prospective survival study in a porcine model

作者:Saxena Payal; Simons Brian W; Gabrielson Kathleen; Haito Chavez Yamile; Valeshabad Ali Kord; Kumbhari Vivek; Singh Vikesh K; Lennon Anne Marie; Canto Marcia Irene; Pasricha Pankaj J; Kalloo Anthony; Khashab Mouen A*
来源:Endoscopy, 2014, 46(7): 605-609.
DOI:10.1055/s-0034-1365406

摘要

Background and study aims: Endoscopic submucosal dissection (ESD) is a technically challenging procedure. A novel gel can facilitate ESD due to its submucosal dissecting properties. This prospective porcine survival study evaluated clinical and histologic parameters of hybrid ESD using the gel. Patients and methods: Gastric submucosal lesions were created in six pigs and hybrid ESD was performed. Healing was assessed weekly until necropsy at Day 28. Results: En bloc resection was achieved in all lesions (mean size 40.7 mm). The mean total procedure time was 13.5 minutes and the mean resec-tion time was 5.5 minutes. The mean total histologic injury score was 4. At necropsy, four ulcers had healed completely and two were <6 mm in size. Conclusion: Hybrid ESD of large gastric lesions in a porcine model can be facilitated by the novel gel, dramatically reducing procedure and resection times by eliminating the need for time-consuming submucosal dissection. The novel gel is safe and easy to use, and has the potential to simplify ESD. Further prospective human studies are needed to validate these findings.

  • 出版日期2014-7