Nasal epithelium integrity, environmental stressors, and allergic sensitization: A biomarker study in adolescents

作者：Sardella Antonia; Voisin Catherine; Nickmilder Marc; Dumont Xavier; Annesi Maesano Isabella; Bernard Alfred^*

来源：Biomarkers, 2012, 17(4): 309-318.

DOI：10.3109/1354750X.2012.666677

• Nasal epithelium
• environmental tobacco smoke
• Clara cell protein
• albumin
• chlorine
• allergy
• permeability
• biomarkers

Changes in the airways epithelium caused by environmental insults might play a role in the development of allergic rhinitis. We measured albumin and Clara cell protein (CC16) in the nasal lavage fluid (NALF) from 474 adolescents (263 girls and 211 boys). The NALF CC16/albumin ratio, integrating the permeability and cellular integrity of the nasal epithelium, decreased mostly with time spent in chlorinated pools. In boys, a lower CC16/albumin ratio in NALF was associated with an increased risk of house dust mite sensitization. The results suggest that

• 出版日期2012-6