科研之友
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摘要
Generalized aggressive periodontitis (GAP) is a subgroup of periodontal diseases among 20-35 years age group adults. Several studies have reported the association of interleukin-1 beta gene polymorphism with periodontal diseases among different populations. The present study aimed at investigating the presence of IL-1 beta polymorphism in GAP patients in Iran. Further, the presence of IL-1 beta(+3954) gene polymorphism was evaluated in the GAP patients (n = 26) and healthy individuals (n = 26). All three genotypes (A1A1 [56%], A1A2 [28%], and A2A2 [16%]) were observed in healthy individuals, whereas only A1A1 (38.5%) and A2A2 (61.5%) were the genotypes observed in the patients. There was a significant positive association between distribution of IL-1 beta genotypes and the risk of periodontitis disease (p = 0.017). Further, there was a significant positive association between probing pocket depth and IL-1 beta genotypes of patients (p = 0.014). However, no meaningful correlation between genotype-clinical attachment loss and genotype bleeding on probing with the risk of GAP (p = 0.418, p = 0.819, respectively) was found. In conclusion, findings of the present study demonstrate a positive association between IL-1 beta gene polymorphism and risk of periodontitis disease.
- 出版日期2013-7
