A New Clerodane Diterpenoid from the Roots of Polyalthia laui Merr.

作者：Li, Xiaobao^*; Song, Xiaoping; Chen, Guangying; Han, Changri; Chen, Wenhao; Zheng, Caijuan; Song, Xinming

来源：Chinese Journal of Organic Chemistry, 2013, 33(6): 1333-1336.

DOI：10.6023/cjoc201305025

• Polyalthia
• Polyalthia laui Merr.
• polyalimide A

Eight clerodane-type compounds were isolated from the roots of Polyalthia laui and purified by silica gel column chromatorgraphy and preparative thin layer chromatorgraphy (TLC). Their structures were elucidated as polyalimide A (1), kolavenic acid (2), 2-oxo-kolavenic acid (3), 2-oxo-14,15-bisnor-3,11E-kolavadien-13-one (4), 3,4-dihydroxyclerodan-13E-en-15-oic acid (5), longimide B (6), 16-oxocleroda-3,13E-dien-15-oic acid (7), and solidagonal acid methyl ester (8). Compound 1 was a novel compound and compound 5 was isolated from this family for the first time, and all compounds were isolated for the first time from this plant material. Compounds 2 and 3 showed weakly inhibitory activities against SPC-A-1, SGC-7901 and K-562 human tumor cells.

• 出版日期2013-6
• 单位海南师范大学