Lung cancer with concurrent EGFR mutation and ROS1 rearrangement: a case report and review of the literature

作者：Zhu, You-cai; Xu, Chun-wei; Ye, Xiao-qian; Yin, Man-xiang; Zhang, Jin-xian; Du, Kai-qi; Zhang, Zhi-hao; Hu, Jian^*

来源：OncoTargets and Therapy, 2016, 9: 4301-4305.

DOI：10.2147/OTT.S109415

• non-small cell lung cancer
• EGFR gene mutation
• ROS1 fusion gene

ROS1 rearrangement has recently emerged as a new molecular subtype in non-small cell lung cancer, and is predominantly found in lung adenocarcinomas compared with other oncogenes such as EGFR, KRAS, or ALK. Patients who have both mutations are extremely rare. Here we report a 50-year-old female diagnosed with adenocarcinoma with sarcomatoid differentiation, who was shown to have EGFR and ROS1 mutations. The patient was treated surgically and received three cycles of adjuvant postoperative chemotherapy. In addition, we reviewed the previously reported cases and related literature. This presentation will provide further understanding of the underlying molecular biology and optimal treatment for non-small cell lung cancer patients with more than one driver mutation.

• 出版日期2016
• 单位中国人民武装警察部队学院; 中国人民解放军军事医学科学院; 浙江大学