Allergen Immunotherapy Outcomes and nmet Needs: A Critical Review

作者：Caimmi Davide; Calderon Moises A; Bousquet Jean; Demoly Pascal^*

来源：Immunology and Allergy Clinics of North America, 2016, 36(1): 181-189.

DOI：10.1016/j.iac.2015.08.011

• Allergen immunotherapy (AIT)
• Allergic rhinitis
• Clinical outcomes
• Primary end point
• Unmet needs

Allergen immunotherapy (AIT) has been evaluated throughout several studies over the last years. A position paper from the European Academy of Allergy and Clinical Immunology highlighted the total combined symptoms score as the method to record the primary end point in AIT studies for allergic rhinitis, but this score still needs to be formally validated and more work done for other allergic diseases. These aspects still seem to be the main unmet need in the evaluation of AIT clinical outcomes in clinical trials.

• 出版日期2016-2