NiCl2-catalyzed cascade reaction of isocyanides with functionalized anilines

作者：Wang Gao Nan; Zhu Tong Hao; Wang Shun Yi^*; Wei Tian Qi; Ji Shun Jun

来源：Tetrahedron, 2014, 70(43): 8079-8083.

DOI：10.1016/j.tet.2014.08.032

• Isocyanide
• Cascade reaction
• Nickel
• Aniline

A NiCl2-catalyzed isocyanide insertion reaction of anilines bearing another nucleophile functional group utilizing TEMPO as oxidant in isopropyl ethanoate (IPA) or THF has been reported. This simple and general method could afford 2-aminobenzimidazole, 2-aminobenzothiazole, 2-aminobenzoxazole, as well as 2-aminobenzo[d][1,3]oxazine in moderate to excellent yields (up to 95% yield).

• 出版日期2014-10-28
• 单位苏州大学