Mathematical Modeling of Drug Release from Natural Polysaccharides Based Matrices

作者：Chiarappa Gianluca; Abrami Michela; Dapas Barbara; Farra Rossella; Trebez Fabio; Musiani Francesco; Grassi Gabriele; Grassi Mario^*

来源：Natural Product Communications, 2017, 12(6): 873-880.

DOI：10.1177/1934578x1701200610

• Mathematical modeling
• Drug release
• Natural polysaccharides
• Matrices

The new concept of personalized medicine and the affirmation of Nucleic Acid Based Drugs (NABDs), an emerging class of bio-drugs constituted by short sequences of either DNA or RNA, represent a new challenge for the mathematical modelling in the drug delivery and adsorption field. Indeed, whether patient uniqueness asks for the use of theoretical tools enabling a rational approach adapting to each patient, NABDs delivery brings to our attention new aspects of drug delivery due to the NABDs fragile nature and way of action. This review aims to present and discuss the mathematical modelling of drug release from natural polysaccharides matrices with particular care to the description of the chemical and physical phenomena ruling drug delivery.

• 出版日期2017-6