Autoimmune disease preceding amyotrophic lateral sclerosis An epidemiologic study

作者：Turner Martin R^*; Goldacre Raph; Ramagopalan Sreeram; Talbot Kevin; Goldacre Michael J

来源：Neurology, 2013, 81(14): 1222-1225.

DOI：10.1212/WNL.0b013e3182a6cc13

Objective: To study whether the risk of amyotrophic lateral sclerosis (ALS) is increased in people with prior autoimmune disease.
Methods: An all-England hospital record-linkage dataset spanning 1999-2011 was used. Cohorts were constructed of people with each of a range of autoimmune diseases; the incidence of ALS in each disease cohort was compared with the incidence of ALS in a cohort of individuals without prior admission for the autoimmune disease.
Results: There were significantly more cases than expected of ALS associated with a prior diagnosis of asthma, celiac disease, younger-onset diabetes (younger than 30 years), multiple sclerosis, myasthenia gravis, myxedema, polymyositis, Sjogren syndrome, systemic lupus erythematosus, and ulcerative colitis.
Conclusions: Autoimmune disease associations with ALS raise the possibility of shared genetic or environmental risk factors.

• 出版日期2013-10-1