APOE gene polymorphism in long-lived individuals from a central China population

作者：Liu, Guodong; Liu, Xiang; Yu, Pulin; Wang, Qi; Wang, Hua^*; Li, Chenfang; Ye, Guangming; Wu, Xiaoling; Tan, Chunling

来源：Scientific Reports, 2017, 7(1): 3292.

DOI：10.1038/s41598-017-03227-5

• APOLIPOPROTEIN-E POLYMORPHISM
• GENOME-WIDE ASSOCIATION
• HUMAN LONGEVITY
• HAN CHINESE
• EXCEPTIONAL LONGEVITY
• ALZHEIMERS-DISEASE
• SURVIVAL
• WORLD
• CENTENARIANS
• DETERMINANTS

Previous studies from European and East Asian cohorts reported conflicting results over whether and how the frequencies of the three common alleles, epsilon 2, epsilon 3 and epsilon 4, of the apolioprotein E gene (APOE), in long-lived individuals differ from those in younger age groups. This study was the first to analyse these frequencies of long-lived individuals from central China. Genotyping of APOE alleles and genotypes was carried out in 70 long-lived individuals and 204 younger controls. No difference in the frequency of any APOE allele or genotype was found between the long-lived participants and their younger controls, but the long-lived group seemed to have a higher epsilon 4 frequency (15.71%) than the 24-50 and 51-75 age groups (10.2% and 11.32%, P > 0.05). Notably, when compared with two other Chinese studies, the central China long-lived group had a higher epsilon 4 frequency than its southern and eastern China counterparts (15.71% vs. 2.82% and 2.54%, P < 0.05). It is not clear to what extent population substructure or lifestyles contributed to these divergent findings. A clear understanding of the contribution of APOE polymorphisms to longevity in the Han Chinese population may be achieved only through large scale studies with participants from well-defined regional clusters.

• 出版日期2017-6-12
• 单位海南医学院; 武汉大学; 北京医院