Aging of Platelet Nitric Oxide Signaling: Pathogenesis, Clinical Implications, and Therapeutics

作者：Procter Nathan E K; Chong Cher Rin; Sverdlov Aaron L; Chan Wai Ping A; Chirkov Yuliy Y; Horowitz John D^*

来源：Seminars in Thrombosis and Hemostasis, 2014, 40(6): 660-668.

DOI：10.1055/s-0034-1389082

• platelet aggregation
• nitric oxide
• aging
• cyclic guanosine monophosphate

The nitric oxide (NO)/soluble guanylate cyclase (sGC) system is fundamental to endothelial control of vascular tone, but also plays a major role in the negative modulation of platelet aggregation. The phenomenon of platelet NO resistance, or decreased antiaggregatory response to NO, occurs increasingly with advanced age, as well as in the context of cardiovascular disease states such as heart failure, ischemic heart disease, and aortic valve disease. The central causes of NO resistance are "scavenging" of NO and dysfunction of sGC. In the current review, we discuss the roles of severalmodulators of NO synthesis and of the NO/sGC cascade on changes in platelet physiology with aging, together with potential therapeutic options to reduce associated thrombotic risk.

• 出版日期2014-9