Association between depression and glycemic control among type 2 diabetes patients in Lima, Peru

作者：Crispin Trebejo Brenda; Cristina Robles Cuadros Maria; Bernabe Ortiz Antonio

来源：Asia-Pacific Psychiatry, 2015, 7(4): 419-426.

DOI：10.1111/appy.12190

<jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>There is limited and controversial information regarding the potential impact of depression on glycemic control. This study aims to evaluate the association between depression and poor glycemic control. In addition, the prevalence of depression and rates of poor glycemic control were determined.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Cross‐sectional study performed in the endocrinology unit of two hospitals of <jats:styled-content style="fixed-case">ESSALUD</jats:styled-content> in <jats:styled-content style="fixed-case">P</jats:styled-content>eru. The outcome of interest was poor glycemic control, evaluated by glycated hemoglobin (<jats:styled-content style="fixed-case">HbA</jats:styled-content>1c: &lt; 7% versus ≥ 7%), whereas the exposure of interest was depression defined as 15 or more points in the Patient Health Questionnaire‐9 tool.</jats:p><jats:p>The association of interest was evaluated using <jats:styled-content style="fixed-case">P</jats:styled-content>oisson regression models with robust standard errors reporting prevalence ratios (<jats:styled-content style="fixed-case">PR</jats:styled-content>) and 95% confidence intervals (95% <jats:styled-content style="fixed-case">CI</jats:styled-content>) adjusting for potential confounders.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 277 participants, 184 (66.4%) males, mean age 59.0 (<jats:styled-content style="fixed-case">SD</jats:styled-content>: 4.8), and 7.1 (<jats:styled-content style="fixed-case">SD</jats:styled-content>: 6.8) years of disease were analyzed. Only 31 participants (11.2%; 95% <jats:styled-content style="fixed-case">CI</jats:styled-content>: 7.5%–14.9%) had moderately severe or severe depression, whereas 70 (25.3%; 95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 20.3%–30.8%) had good glycemic control. Depression increased the probability of having poor glycemic control (<jats:styled-content style="fixed-case">PR</jats:styled-content> = 1.32; 95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 1.15–1.51) after adjusting for several potential confounders.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>There is an association between depression and poor glycemic control among type 2 diabetes patients. Our results suggest that early detection of depression might be important to facilitate appropriate glycemic control and avoid further metabolic complications.</jats:p></jats:sec>

• 出版日期2015-12