科研之友
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摘要
Background: Despite its frequency, the polycystic ovary syndrome (PCOS) is still a difficult diagnosis in endocrinology, gynecology, and reproductive medicine. The Rotterdam consensus conference proposed to include the ultrasonographic follicle count as a new diagnostic criterion. Unfortunately, its assessment does not offer sufficient reliability worldwide. %26lt;br%26gt;Objective: To explore the possible roles of altered circulating androgens and anti-mullerian hormone among PCOS women regarding their body mass index and their outcomes after IVF. %26lt;br%26gt;Materials and Methods: In this cross sectional study, 195 women with PCO were included, they were divided according to their body mass index (BMI %26lt;27 kg/m(2)) as obese PCOS (n=91) and overweight PCOS (BMI %26gt;= 27 kg/m(2)) (n=104). Serum levels of androgens (dehydroepiandrosterone sulfate [DHEAS], testosterone and androstenedione [A4]), and anti-mullerian hormone (AMH) were assessed and compared with the endocrine profile and cycles outcomes. %26lt;br%26gt;Results: AMH, A4, FSH, and TSH concentrations were significantly higher in obese than in overweight women (p%26lt;0.001). Contrary, LH: FSH ratio values, E-2, PRL and DAHE-S levels were significantly lower in obese than in overweight women (p%26lt;0.0001). Total oocyte retrieved, mature and fertilized oocyte were significantly higher in obese than in overweight women. Among pregnant obese PCOS women both AMH and A4 were significantly increased and DAHE-S was significantly decreased compared to pregnant overweight PCOS women. %26lt;br%26gt;Conclusion: Obese PCOS women have a higher chance of getting pregnant over those categorized as overweight PCOS. Also, androgens and AMH levels recommended to be considered in IVF attributes among obese and overweight PCOS women.
- 出版日期2013-11
