Association between sclerostin, serum bone turnover markers and bone density in postmenopausal women with fragility fracture

作者：Zou, Jian; Li, Xiaolin^*; Yang, Fan

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(7): 12984-12991.

• Osteoporosis
• sclerostin
• postmenopausal

In this study we sought to determine the relationship between circulating sclerostin levels, serum bone turnover markers and bone mass in postmenopausal women with fragility fracture. 80 premenopausal women and 80 postmenopausal women with femoral neck fracture were evaluated in a cross-sectional observational study. There were significant differences between the two groups in bone turnover makers. Serum sclerostin levels were higher in postmenopausal women. There was a significant negative correlation between serum sclerostin level and mean femoral neck BMD, mean trochanter BMD and mean total hip BMD in postmenopausal women. No significant correlations were seen between serum sclerostin levels and lumbar spine BMD or serum bone turnover markers in either group. There was significant positive correlation between serum sclerostin level and age in combined pre-and postmenopausal women. But there was no correlation in either group separately. In the postmenopausal women, there were no significant correlations between serum sclerostin levels and any of the measured bone turnover markers. We conclude that measurement of serum sclerostin levels may represent a novel approach to predict the potential risks of fraglity fracture in postmenopausal women.

• 出版日期2016
• 单位上海交通大学