AN UNUSUAL CASE OF MULTI-RECURRENT HERPES ZOSTER (HZ): A CASE REPORT

作者：Bostikova Vanda^*; Salavec Miloslav; Smetana Jan; Chlibek Roman; Kosina Pavel; Prasil Petr; Plisek Stanislav; Splino Miroslav; Bostik Pavel

来源：Biomedical Papers-Olomouc, 2011, 155(4): 397-401.

DOI：10.5507/bp.2011.062

• Herpes zoster
• Varicella-zoster virus
• Wild-type strain
• Czech Republic

Aims. We report a case of multi-recurrent herpes zoster in a 53-year-old Caucasian woman treated repeatedly at the Faculty Hospital Hradec Kralove, Czech Republic over the years 2009 - 2011.
Methods. Specific PCR methods targeting single nucleotide polymorphisms (SNPs) in open reading frames (ORF) 38, 54 and 62 were utilized to determine vaccine or wild type varicella-zoster (VZV) strains followed by SNPs analysis using two amplicons in ORF 22 and/or ORF 21/ORF 50. Additional genotyping in ORF 1, 6, 9 and 28 was subsequently performed due to the unusual results.
Results. Three sets of clinical specimens from one patient (from hospital visits 2, 3 and 4) were analyzed and the presence of an unusual wild-type strain of VZV was discovered. The VZV strain isolated from the lesions bears a combination of markers characteristic both for Mosaic 2 (M2) and European 1 (E1) wild-type VZV strains.
Conclusion. This is the first report of atypical wild-type VZV strain circulating currently in Czech Republic.

• 出版日期2011