Development of a silk fibroin/HTCC/PVA sponge for chronic wound dressing

作者：Li Xiaomeng; Li Binghui; Ma Jun^*; Wang Xiaoyu; Zhang Shengming

来源：Journal of Bioactive and Compatible Polymers, 2014, 29(4): 398-411.

DOI：10.1177/0883911514537731

• Wound dressing
• silk fibroin
• composite sponge
• chronic wound
• blended sponge
• N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride
• polyvinyl alcohol

A sponge wound dressing comprising silk fibroin, N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride, and polyvinyl alcohol was developed for chronic wound healing. These composite sponges were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. The composite sponge had a fluid uptake of 80% of its weight, and the water vapor transmission rate of 2974 +/- 684 g/m(2)/day, indicating that the sponge could keep a moist environment around the wound bed. The Wistar rats were used to evaluate these composites for the treatment of chronic wounds. Wound healing was monitored through the macroscopic and immunological analyses. Although the wound area reduction rates were similar for the composite dressings compared to the non-woven fabrics containing wax-oil, the new composite dressings were found to be capable of improving the formation of blood vessels inside the wound beds by promoting the regrowth of skin tissues. Based on these results, using aqueous composite sponges in wound dressings, instead of oil-containing fabrics, promotes healing of chronic wounds in clinical applications.

• 出版日期2014-7
• 单位华中科技大学