Association of N-Linked Glycoprotein Acetyls and Colorectal Cancer Incidence and Mortality

作者：Chandler Paulette D^*; Akinkuolie Akintunde O; Tobias Deirdre K; Lawler Patrick R; Li Chungying; Moorthy M Vinayaga; Wang Lu; Duprez Daniel A; Jacobs David R; Glynn Robert J; Otvos James; Connelly Margery A; Post Wendy S; Ridker Paul M; Manson Joann E; Buring Julie E; Lee I Min; Mora Samia^*

来源：PLos One, 2016, 11(11): e0165615.

DOI：10.1371/journal.pone.0165615

Background
Acute phase proteins highlight the dynamic interaction between inflammation and oncogenesis. GlycA, a novel nuclear magnetic resonance (NMR) inflammatory marker that identifies primarily circulating N-acetyl glycan groups attached to acute phase proteins, may be a future CRC risk biomarker.
Methods
We examined the association between GlycA and incident CRC and mortality in two prospective cohorts (N = 34,320); Discovery cohort: 27,495 participants from Women's Health Study (WHS); Replication cohort: 6,784 participants from Multi-Ethnic Study of Atherosclerosis (MESA). Multivariable Cox models were adjusted for clinical risk factors and compared GlycA to acute phase proteins (high-sensitivity C-reactive protein [hsCRP], fibrinogen, and soluble intercellular adhesion molecule-1 [sICAM-1]).
Results
In WHS (median follow-up 19 years, 337 cases, 103 deaths), adjusted HRs (95% CIs) per SD increment of GlycA for CRC incidence and mortality were 1.19 (1.06-1.35; p = 0.004) and 1.24 (1.00-1.55; p = 0.05), respectively. We replicated findings in MESA (median follow-up 11 years, 70 cases, 23 deaths); HRs (95% CIs) per SD of GlycA for CRC incidence and mortality were 1.32 (1.06-1.65; p = 0.01) and 1.54 (1.06-2.23; p = 0.02), respectively, adjusting for age, sex, and race. Pooled analysis, adjusted HR (95% CI) per SD of GlycA for CRC incidence and mortality was 1.26 (1.15-1.39; p = 1 x 10(-6)). Other acute phase proteins (hsCRP, fibrinogen, and sICAM-1) had weaker or no association with CRC incidence, while only fibrinogen and GlycA were associated with CRC mortality.
Conclusions
The clinical utility of GlycA to personalize CRC therapies or prevention warrants further study.

• 出版日期2016-11-30