Vitamin D and innate immunity

作者：Hewison Martin^*

来源：Current Opinion in Investigational Drugs, 2008, 9(5): 485-490.

• antibacterial
• cathelicidin
• CYP27b1
• macrophage
• TLR
• vitamin D
• vitamin D receptor

It is becoming increasingly clear that vitamin D can exert effects on human physiology beyond its long-standing association with skeletal homeostasis. In particular, the ability of active 1,25-dihydroxyvitamin D ( 1,25( OH) 2 D) to function as a potent modulator of human immune responses has attracted much attention. Over the last ten years, most studies on the relationship between vitamin D and immunity have focused on the effects of 1,25( OH) 2 D on lymphocytes and adaptive immunity; however, studies have shown that local macrophage synthesis of 1,25( OH) 2 D in response to TLR signaling is also a key feature of innate immunity. This new facet of 'non-classical' roles of vitamin D action is discussed in this review.

• 出版日期2008-5