Maternal Magnesium Sulphate Exposure Predicts Neonatal Magnesium Blood Concentrations

作者：Sherwin Catherine M T^*; Balch Alfred; Campbell Sarah C; Fredrickson Jeunesse; Clark Erin A S; Varner Michael; Stockmann Chris; Korgenski E Kent; Bonkowsky Joshua L; Spigarelli Michael G

来源：Basic and Clinical Pharmacology and Toxicology, 2014, 114(4): 318-322.

DOI：10.1111/bcpt.12166

Tocolytic use of magnesium sulphate is associated with excess neonatal mortality and has been proposed to follow a dose-response relationship. This study aimed to define the correlation between maternal and neonatal magnesium blood concentrations. Magnesium blood concentrations were retrospectively obtained for mother-neonate pairs who were cared for at an Intermountain Healthcare facility from January 2009 to October 2011. Complete data were available for 231 mother-neonate pairs. Mean (+/- SD) maternal and neonatal magnesium concentrations were 5.43 +/- 1.69 and 2.98 +/- 0.94mg/dL, respectively. Maternal and neonatal magnesium concentrations were highly correlated (p<0.001). In univariate analyses, residual unexplained variability was high (r(2)=0.19). However, further multivariate analyses revealed that caesarian section, severe pre-eclampsia and Apgar score at 5min. were significantly associated with neonatal magnesium concentrations (p<0.05 for all). Maternal magnesium concentrations correlate with neonatal exposure. This finding suggests that maternal monitoring deserves further evaluation as a marker of foetal toxicity.

• 出版日期2014-4