Antinociceptive effect of Lafoensia pacari A. St.-Hil. independent of anti-inflammatory activity of ellagic acid

作者：Mariano Nascimento Marcus Vinicius; Galdino Pablinny Moreira; Florentino Iziara Ferreira; Sampaio Bruno Leite; Vanderlinde Frederico Argollo; de Paula Jose Realino; Costa Elson Alves

来源：Journal of Natural Medicines, 2011, 65(3-4): 448-454.

DOI：10.1007/s11418-011-0517-y

• Medicinal plants
• Analgesic activity
• Bioactivity-guided fractionation
• Neurogenic pain
• Formalin test

This study was performed to determine the antinociceptive and anti-inflammatory activities of ethanolic extract of Lafoensia pacari A. St.-Hil. (PEtExt) stem bark and its fractions using various animal models such as acetic acid-induced abdominal writhing, formalin-induced pain and croton oil-induced ear edema tests. The PEtExt inhibited the acetic acid-induced abdominal writhing, reduced the pain reaction time on both phases of the formalin test and decreased the edema in a dose-dependent manner. Pre-treatment with naloxone did not reverse the antinociceptive effect. Only the ethyl acetate fraction showed antinociceptive and anti-inflammatory effects. Our results also showed that this extract contains compounds with analgesic action independent of anti-inflammatory activity.

• 出版日期2011-7