A FACILE SYNTHESIS OF SYMMETRICAL AND UNSYMMETRICAL BIS(INDOLYL)ACETAMIDES MEDIATED BY PROTIC ACID

作者：Shang, Hai^*; Hao, Fei-Yue; Pan, Li; Chen, Hong; Cheng, Mao-Sheng

来源：Heterocycles, 2011, 83(8): 1757-1769.

DOI：10.3987/COM-11-12220

• Synthesis
• Symmetrical Bisindolylacetamide
• Unsymmetrical Bisindolylacetamide
• Protic Acid
• Mechanism

We report the preparation of symmetrical bis(indolyl)acetamides using the dimerization of 2-hydroxy-(2-indolyl)acetamides and unsymmetrical bis(indolyl)acetamides via electrophilic substitution of indoles with 2-hydroxy-(2-indolyl)acetamides. Both conversions were mediated by protic acid in THF at room temperature.

• 出版日期2011-8-1
• 单位沈阳药科大学; 中国人民武装警察部队后勤学院