Undetectable pre-ablation thyroglobulin levels in patients with differentiated thyroid cancer: it is not always what it seems

作者：Pitoia Fabian^*; Bueno Maria F; Abelleira Erika; Salvai Maria E; Bergoglio Liliana; Luster Markus; Niepomniszcze Hugo

来源：Arquivos Brasileiros de Endocrinologia e Metabologia, 2013, 57(4): 300-306.

• Undetectable thyroglobulin levels
• thyroglobulin
• ablation
• thyroid
• cancer

Objective: To establish the frequency of U Tg (undetectable pre-ablation thyroglobulin) in TgAb-negative patients and to evaluate the outcome in the follow-up. Subjects and methods: We retrospectively reviewed 335 patients%26apos; records. Twenty eight patients (9%) had U Tg. Mean follow-up was 42 +/- 38 months. All subjects had undergone total thyroidectomy, and lymph nodes were positive in 13 (46%) patients. Tg and TgAb levels were measured 4 weeks after surgery by IMA technology in hypothyroid state. No evidence of disease (NED) status was defined as undetectable (%26lt; 1 ng/mL) stimulated Tg and negative Tg-Ab and/or negative WBS, together with normal imaging studies. Results: Seventeen patients (61%) were considered with NED. Four patients (14%) had persistent disease (mediastinum, n = 1, lung n = 2, unknown n = 1), and 7 (25%) had detectable TgAb by other method during their follow-up. Conclusions: U Tg levels usually is associated to a complete surgery. However, in a low percentage of patients, this may be related to false negative Tg or TgAb measurement. Arq Bras Endocrinol Metab. 2013;57(4):300-6

• 出版日期2013-6