Sialyl alpha(2 -> 3) lactose clusters using carbosilane dendrimer core scaffolds as influenza hemagglutinin blockers

作者：Oka Hiroyuki; Onaga Tomotsune; Koyama Tetsuo; Guo Chao Tan; Suzuki Yasuo; Esumi Yasuaki; Hatano Ken; Terunuma Daiyo; Matsuoka Koji^*

来源：Bioorganic & Medicinal Chemistry Letters, 2008, 18(15): 4405-4408.

DOI：10.1016/j.bmcl.2008.06.101

• sialyl lactose
• hemagglutinin
• sialic acid
• influenza virus
• dendrimers
• carbosilanes
• glycoclusters

An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with sialyl alpha(2 -> 3) lactose (Neu5Ac alpha(2 -> 3)Gal beta(1 -> 4)Glc beta 1 ->) moieties was accomplished. The results of a preliminary study on biological responses against influenza virus hemagglutinin, using the sialyl lactose clusters showed unique biological activities on the basis of the structure-activity relationship according to the carbosilane scaffolds.

• 出版日期2008-8-1
• 单位浙江省医学科学院