Application of magnetic nanoparticle-supported CuBr: a highly efficient and reusable catalyst for the one-pot and scale-up synthesis of 1,2,3-triazoles under microwave-assisted conditions

作者：Xiong Xingquan^*; Cai Lei

来源：Catalysis Science & Technology, 2013, 3(5): 1301-1307.

DOI：10.1039/c3cy20680g

An efficient and practical approach was developed to synthesize 1,2,3-triazoles using recyclable Fe3O4 magnetic nanoparticle (MNP)-supported copper(I) catalysts via a one-pot multi-component copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction in water. Under microwave irradiation conditions, terminal alkynes reacted quickly with benzyl/alkyl azides, which were generated in situ from corresponding primary halides and sodium azide. The 1,2,3-triazoles can be exclusively generated in good to excellent yields and on a multi-gram scale.

• 出版日期2013
• 单位华侨大学