Nanocrystalline boron-doped diamond nanoelectrode arrays for ultrasensitive dopamine detection

作者：Dincer Can^*; Ktaich Rabih; Laubender Elmar; Hees J Jakob; Kieninger Jochen; Nebel Christoph E; Heinze Juergen; Urban Gerald A

来源：Electrochimica Acta, 2015, 185: 101-106.

DOI：10.1016/j.electacta.2015.10.113

• Boron-doped diamond
• Oxygen termination
• Nanoelectrode arrays
• Dopamine
• Ascorbic acid
• Differential pulse voltammetry

In this paper we present nanocrystalline boron-doped diamond nanoelectrode arrays (BDD-NEAs) for the low-level detection of biogenic substances such as dopamine (DA) without the need for a selective membrane. We achieved a sensitive and reproducible detection of dopamine in the presence of ascorbic acid (AA) with oxygen (O-) terminated BDD-NEAs. To improve the peak separation between dopamine and ascorbic acid, differential pulse voltammetry (DPV) was employed. Therewith, it was possible to measure dopamine with a sensitivity of 57.9 nA mu M-1 cm(-2). The detection limit was less than 100 nM with a linear behavior up to a concentration of 20 mu M. The choice of the appropriate termination, the combination of the advantages of nanoelectrode arrays together with the outstanding electrochemical properties of boron-doped diamond and the right measurement method allowed successful measurement of dopamine in physiological concentrations in the presence of ascorbic acid.

• 出版日期2015-12-10