Association Analysis of ANK3 Gene Variants in Nordic Bipolar Disorder and Schizophrenia Case-Control Samples

作者：Tesli Martin^*; Koefoed Pernille; Athanasiu Lavinia; Mattingsdal Morten; Gustafsson Omar; Agartz Ingrid; Rimol Lars M; Brown Andrew; Wirgenes Katrine V; Smorr Lisa Lena; Kahler Anna K; Werge Thomas; Mors Ole; Mellerup Erling; Jonsson Erik G; Melle Ingrid; Morken Gunnar; Djurovic Srdjan; Andreassen Ole A

来源：American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 2011, 156B(8): 969-974.

DOI：10.1002/ajmg.b.31244

• bipolar disorder
• schizophrenia
• ANK3
• genetic association

Genetic variants in ankyrin 3 (ANK3) have recently been shown to be associated with bipolar disorder (BD). We genotyped three ANK3 SNPs previously found to be associated with BD (rs10994336, rs1938526, and rs9804190) in a Scandinavian BD case-control sample (N = 854/2,614). Due to evidence of genetic overlap between BD and schizophrenia (SZ), we also genotyped these three SNPs in a Scandinavian SZ case-control sample (N = 1,073/2,919). Combining our Scandinavian samples with an Icelandic sample (N = 435 BD cases, 651 SZ cases, and 11,491 healthy controls), we found rs10994336 and rs9804190 to be nominally significantly associated with BD in this combined Nordic BD sample (N = 1,289/14,105). Nominal P was 0.015/0.018 (fixed/random effect) for rs10994336 (Bonferroni corrected P = 0.044/0.053) and 0.023 for rs9804190 (Bonferroni corrected P = 0.069). None of the SNPs were significantly associated with SZ in the combined Nordic SZ case-control sample (N = 1,724/14,410). These results further support that ANK3 is a susceptibility gene specific to BD and that more than one risk locus is involved.

• 出版日期2011-12
• 单位上海市精神卫生中心