Association Between Hepatocellular Carcinoma and Type 2 Diabetes Mellitus in Chinese Hepatitis B Virus Cirrhosis Patients: A Case-Control Study

作者：Han, Huixian; Deng, Han; Han, Tao; Zhao, Haitao; Hou, Feifei; Qi, Xingshun^*

来源：MEDICAL SCIENCE MONITOR, 2017, 23: 3324-3334.

DOI：10.12659/MSM.902440

• Carcinoma
• Hepatocellular
• Diabetes Mellitus
• Hepatitis B Virus
• Liver Cirrhosis
• Risk Factors

Background: Whether the presence of type 2 diabetes mellitus (T2DM) increases the risk of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) cirrhosis patients is controversial. We conducted a retrospective case-control study to evaluate this issue.
Material/Methods: We considered all patients diagnosed with HBV-related liver cirrhosis at our hospital from July 2011 to June 2014. The case (n=91) and control (n=91) groups were HBV cirrhosis patients with and without T2DM, respectively. They were matched at a ratio of 1: 1 according to the individual age (+/- 2 years) and same sex and Child-Pugh score.
Results: None of the baseline data were significantly different between the 2 groups. The percentage of HCC was similar between the 2 groups (case versus control group: 34.1% versus 46.2%, P=0.13). In the case group, sex (P=0.002), alkaline phosphatase (P<0.001), gamma-glutamine transferase (P=0.001), and sodium (P=0.003) were associated with the risk of HCC. In the control group, platelet (P=0.041), alanine aminotransferase (P=0.034), aspartate aminotransferase (P=0.026), alkaline phosphatase (P<0.001), and gamma-glutamine transferase (P<0.001) were associated with the risk of HCC.
Conclusions: T2DM may not be a risk factor for the presence of HCC in HBV cirrhosis.

• 出版日期2017-7-9
• 单位中国人民解放军沈阳军区总医院; 大连医科大学