First heterogeneously palladium-catalysed fully selective C3-arylation of free NH-indoles

作者：Cusati Giuseppe; Djakovitch Laurent^*

来源：Tetrahedron Letters, 2008, 49(16): 2499-2502.

DOI：10.1016/j.tetlet.2008.02.130

• Indoles
• selective C3-arylation
• palladium
• heterogeneous catalysis

A simple heterogeneously palladium-catalysed procedure for the selective C3-arylation of indoles is reported. Under relatively standard reaction conditions (Pd-catalyst, K(2)CO(3), dioxane, reflux), using only 1 mol % [Pd(NH(3))(4)]/NaY as the catalyst, indoles substituted or not at position 2 gave up to 92% conversion (i.e., 85% isolated yield) towards the expected C3-arylated indole.

• 出版日期2008-4-14