Delineating the cellular pathways of hematopoietic lineage commitment

作者：Luc Sidinh; Buza Vidas Natalija; Jacobsen Sten Eirik W^*

来源：Seminars in Immunology, 2008, 20(4): 213-220.

DOI：10.1016/j.smim.2008.07.005

• hematopoietic stem cells
• lineage commitment
• lymphoid-primed multipotent progenitors
• fetal
• transcriptional priming

The prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (LMPPs) and primitive common myeloid progenitors (CMPs) within the "HSC" compartment provide compelling support for establishment of independent GM-megakaryocyte/erythroid (GM-MkE) and GM-lymphoid commitment pathways as decisive early lineage fate decisions. These changes in lineage potentials are corroborated by corresponding changes in multilineage transcriptional priming, as LMPPs down-regulate MkE priming but become GM-lymphoid transcriptionally primed, whereas CMPs are GM-MkE primed. These distinct biological and molecular relationships are established already in the fetal liver.

• 出版日期2008-8