Asymmetric and diastereoselective Mannich reactions using hydantoin as a chiral auxiliary

作者：Li Xuan Ran; Lu Cui Fen; Chen Zu Xing; Li Yan; Yang Gui Chun^*

来源：Tetrahedron: Asymmetry , 2012, 23(18-19): 1380-1384.

DOI：10.1016/j.tetasy.2012.09.006

The Mannich reaction of titanium enolates of a chiral hydantoin with various aldimines smoothly occurred in good yields and with high anti-diastereoselectivity. The Mannich adducts can be readily cleaved by alcoholysis to afford several beta-amino ester derivatives in good yields and in almost enantiomerically pure form.

• 出版日期2012-10-15
• 单位湖北大学