Diastereoselective syntheses of 3-aryl-5-(arylalkyl)-6-methyl-1-(1-phenylethyl)thioxotetrahydropyrimidin -4(1H)-ones: A stereochemical perspective from endo and exocyclic chiral centres

作者：Kumar Varun; Raghavaiah Pallepogu; Mobin Shaikh M; Nair Vipin A^*

来源：Organic and Biomolecular Chemistry, 2010, 8(21): 4960-4970.

DOI：10.1039/c0ob00230e

Diastereoselective syntheses of 3-aryl-(S/R)-6-methyl-1-[(S/R)-1-phenylethyl)]-2-thioxotetrahydro pyrimidin-4(1H)-ones were achieved in good yields by the condensation of aryl isothiocyanates with ethyl 3-(1-phenylethylamino) butanoate in a one-pot reaction. Benzylation of these substrates illustrated that the orientations of the exocylic and endocylic groups determine the stereochemical outcome of the product formed.

• 出版日期2010