Assessing colorectal cancer heterogeneity: one step closer to tailored medicine

作者：Pitule Pavel^*; Cedikova Miroslava; Treska Vladislav; Kralickova Milena; Liska Vaclav

来源：Journal of Applied Biomedicine, 2013, 11(3): 115-129.

DOI：10.2478/v10136-012-0035-6

• colorectal cancer
• chromosomal instability
• microsatellite instability
• CpG island methylator phenotype
• EGFR pathway
• circulating tumour cells
• stool DNA

Many advances in understanding colorectal cancer heterogeneity and its impact on the variability of treatment efficacy have been achieved in recent years. New methods have also been introduced in colorectal cancer diagnosis and early detection, including molecular biology techniques as well as newly developed or improved imaging techniques. We are currently aware of some aspects of colorectal cancer heterogeneity, such as alterations in the epidermal growth factor receptor signalling or the different behaviours of tumours belonging to different genetic and epigenetic subtypes. In the future, greater attention should also be focused on other signalling circuits with the goal to treat patients individually, based on the characteristics of their tumours. This so-called personalised medicine will bring more benefits to patients, without unnecessary adverse side effects. Therefore, all new information regarding colorectal cancer biology brings us one step closer to accomplishing this goal.

• 出版日期2013