科研之友
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摘要
In traditional system of medicine, Strychnos potatorum Linn. seeds were used for various ailments like pain, inflammation, anemia, jaundice, bronchitis, diabetes, conjunctivitis, chronic diarrhoea, dysentery etc. To investigate the folkloric use, the present study was carried out to evaluate the antinociceptive and antipyretic activities of seed powder (SPP) and aqueous extract (SPE) of Strychnos potatorum Linn seeds in experimental wistar albino mice and rats, respectively. The antinociceptive activity was studied in both chemical [acetic acid (1 mL/100 g b.wt.) induced writhing] and thermal (hot plate and tail immersion technique) models of inducing nociception. Administration of SPP and SPE at two dose levels (100 and 200 mg kg(-1) p.o.) significantly (p<0.001) decreased the abdominal contractions in acetic acid induced writhing model and significantly (p<0.001) increased the reaction time in both hot plate and tail immersion techniques, when compared with the standard drug Aspirin (100 mg kg(-1), p.o.). Thus SPP and SPE were found to exhibit antinociceptive activity in both chemical and thermal models indicating their central as well as peripheral mechanisms in inhibiting the nociception, respectively. The antipyretic activity was studied by injecting TAB vaccine at the dose of 1 mL kg(-1) b.wt., where the pyresis was induced after 6 h. Both SPP and SPE exhibited dose dependent activity in reducing the pyrexia which is comparable to that of Paracetamol (100 mg kg(-1), p.o.).
- 出版日期2010-10
