Antioxidant responses in different body regions of the polychaeta Laeonereis acuta (Nereididae) exposed to copper

作者：Ferreira Cravo Marlize; Ventura Lima Juliane; Sandrini Juliana Zomer; Amado Lilian Lund; Geracitano Laura Alicia; Rebelo Mauro; Bianchini Adalto; Monserrat Jose Maria^*

来源：Ecotoxicology and Environmental Safety, 2009, 72(2): 388-393.

DOI：10.1016/j.ecoenv.2008.07.003

• Copper toxicity
• Oxidative stress
• Total antioxidant capacity
• DNA damage
• Polychaeta

Antioxidant enzymes, total antioxidant capacity (TOSC) and concentration of reactive oxygen species (ROS) were measured in anterior (A), middle (M) and posterior (P) body regions of Laeonereis acuta after copper (Cu; 62.5 mu g/l) exposure. A catalase (CAT) activity gradient observed in control group (lowest in A, highest in P) was not observed in Cu exposed group. Glutathione-S-transferase (GST) activity in A region of Cu group was higher than in A region of the control group. DNA damage (comet assay) was augmented in the A region of Cu group. Since copper accumulation was similar in the different body regions, sensitivity to copper in A regions seems to be related to lowest CAT activity. In sum, copper exposure lowered TOSC, a result that at least in part can be related to lowering of antioxidant enzymes like CAT. DNA damage was induced in the anterior region, where a lower CAT activity was observed.

• 出版日期2009-2