A novel composite scaffold comprising ultralong hydroxyapatite microtubes and chitosan: preparation and application in drug delivery

作者：Zhang, Yong-Gang; Zhu, Ying-Jie^*; Chen, Feng; Sun, Tuan-Wei

来源：Journal of Materials Chemistry B, 2017, 5(21): 3898-3906.

DOI：10.1039/c6tb02576e

• POROUS HOLLOW MICROSPHERES
• CALCIUM OLEATE PRECURSOR
• BONE REGENERATION
• HYDROTHERMAL SYNTHESIS
• MECHANICAL-PROPERTIES
• IN-VITRO
• REINFORCED HYDROXYAPATITE
• PROTEIN ADSORPTION
• PHOSPHORUS SOURCE
• PHOSPHATE

In this work, a novel ultralong hydroxyapatite microtube (HMT)-chitosan (CHS) composite scaffold has been successfully prepared. The mechanical properties of the HMT-CHS composite scaffold is greatly improved compared with the CHS-hydroxyapatite nanorod scaffold and the pure chitosan scaffold. By using gentamicin sulfate (GS) as the model drug, the GS-loaded HMT-CHS composite scaffold has a high drug loading capacity, sustained drug release behavior and high antibacterial activity. The as-prepared HMT-CHS composite scaffold has promising applications in various fields such as drug delivery and bone defect repair.

• 出版日期2017-6-7
• 单位中国科学院; 中国科学院上海硅酸盐研究所; 高性能陶瓷和超微结构国家重点实验室; 中国科学院大学