Nuclear factor-kappa B and the hepatic inflammation-fibrosis-cancer axis

作者：Elsharkawy Ahmed M; Mann Derek A^*

来源：Hepatology, 2007, 46(2): 590-597.

DOI：10.1002/hep.21802

Nuclear factor-kappa B (NF-kappa B) is a transcriptional regulator of genes involved in immunity, inflammatory response, cell fate, and function. Recent attention has focused on the pathophysiological role of NF-kappa B in the diseased liver. In vivo studies using rodent models of liver disease and cell-targeted perturbation of NF-kappa B activity have revealed complex and multicellular functions in hepatic inflammation, fibrosis, and the development of hepatocellular carcinoma-a process we have termed the "inflammation-fibrosis-cancer axis". This review summarizes the current state of knowledge and provides insight into the vast complexity of the hepatic NF-kappa B signaling system, which should provide a rich source of new therapeutic targets.

• 出版日期2007-8